CORE 2 MUSCULOSKELETAL RESEARCHERS

Core 2 Musculoskeletal Researchers2020-08-25T16:02:18+00:00

Below is a list of multidisciplinary Core competencies that support the breadth of Regenerative Rehabilitation research. Select one to learn about AR3T’s researchers with expertise in that area. Learn more about collaborative projects, consultations and sabbatical experiences that are available through the AR3T resource center here.

Core 2: Mechanotransductive Methods

Musculoskeletal (hard and soft tissue) researchers:

  • Wagner Laboratory: The primary research interests of Dr. William Wagner’s Laboratory at the McGowan Institute for Regenerative Medicine are in the area of cardiovascular engineering with projects that address medical device biocompatibility and design, tissue engineering, and targeted imaging. Dr. Wagner’s laboratory brings expertise in structural mechanics for the assessment of tissue biophysical properties.
  • Ambrosio Laboratory: Dr. Fabrisia Ambrosio’s research has the long-term goal of developing Regenerative Rehabilitation approaches to improve the skeletal muscle healing and functional recovery. Her laboratory uses murine and human models to investigate the underlying mechanisms by which targeted and specific mechanotransductive signals can be used to enhance donor and/or host stem cell functionality.
  • Boninger Laboratory: Dr. Michael Boninger’s research efforts at both Pitt and the VA focus on technologies to improve the lives of individuals with spinal cord injury and other disabilities. His teams wheelchair work – conducted primarily at Pittsburgh Human Engineering Research Laboratories, where he is medical director – has led to patents for devices used throughout the world. In addition, his team discovered a link between how a person propels a manual wheelchair and his or her risk of injuries, such as rotator cuff tears.
  • George Laboratory: Paul George’s laboratory focuses on applying biomaterials to interact with the nervous system in new ways and determining important mechanisms of neural recovery.  Electrical stimulation is being studied as a potential mechanism for manipulating stem cells in vivo. Through the use of engineered biomaterials, he hopes to create the optimal environment for neural recovery.
  • Smith Laboratory: Jay Smith studies the clinical applications of musculoskeletal ultrasound for diagnostic and interventional procedures. He also studies regenerative medicine approaches in combination with ultrasound to enhance patient care including delivery of platelet rich plasma, bone marrow concentrate and other Orthobiologic agents into joints and soft tissues. Multiple studies are examining the outcomes of treatments using autologous, culture expanded adipose derived mesenchymal stem cells. He also has expertise in shoulder and elbow biomechanics.
  • Ambrosio Laboratory: Dr. Fabrisia Ambrosio’s research has the long-term goal of developing Regenerative Rehabilitation approaches to improve the skeletal muscle healing and functional recovery. Her laboratory uses murine and human models to investigate the underlying mechanisms by which targeted and specific mechanotransductive signals can be used to enhance donor and/or host stem cell functionality.
  • Wang Laboratory: Dr. James H-C. Wang’s laboratory studies the cellular and molecular mechanisms for the development of tendinopathy using in vitro and in vivo model systems, and enhancing the biological and biomechanical properties of healing tendons and ligaments using functional tissue engineering approaches. Dr. Wang is also interested in understanding how mechanical forces are transmitted to cells and translated into anabolic or catabolic responses. Currently, his major research effort is on tendon stem cell mechanobiology and on the use of platelet-rich plasma to enhance the healing of injured tendons.
  • Watkins Laboratory: Dr. Simon Watkins is the founder and director of the Center for Biologic Imaging at the University of Pittsburgh and a member of the Pittsburgh Cancer Institute.
  • Ambrosio Laboratory: Dr. Fabrisia Ambrosio’s research has the long-term goal of developing Regenerative Rehabilitation approaches to improve the skeletal muscle healing and functional recovery. Her laboratory uses murine and human models to investigate the underlying mechanisms by which targeted and specific mechanotransductive signals can be used to enhance donor and/or host stem cell functionality.
  • Boninger Laboratory: Dr. Michael Boninger’s research efforts at both Pitt and the VA focus on technologies to improve the lives of individuals with spinal cord injury and other disabilities. His teams wheelchair work – conducted primarily at Pittsburgh Human Engineering Research Laboratories, where he is medical director – has led to patents for devices used throughout the world. In addition, his team discovered a link between how a person propels a manual wheelchair and his or her risk of injuries, such as rotator cuff tears.