CORE 1 CARDIOVASCULAR RESEARCHERS

Core 1 Cardiovascular Researchers2018-09-19T15:33:08+00:00

Below is a list of multidisciplinary Core competencies that support the breadth of Regenerative Rehabilitation research. Select one to learn about AR3T’s researchers with expertise in that area. Learn more about collaborative projects, consultations and sabbatical experiences that are available through the AR3T resource center here.

Core 1: Cellular Therapeutics/Tissue Engineering

Cardiovascular researchers:

  • Suggs Laboratory: Dr. Laura Suggs’ lab aims to develop clinically relevant and robust strategies for enhancing the growth of cardiac and vascular tissue in vivo to restore function after injuries such as myocardial infarction, ischemia, and deep burns. Toward this goal this lab studies the in vitro response of stem cells to pro-angiogenic gel materials that they have developed, explores new strategies to encourage stem cell differentiation to cardiomyocytes, and assesses the vessel forming ability of stem cells implanted within gel scaffolds in mouse injury models. They are also interested in creating novel self-assembling gel matrix materials for promoting angiogenesis that are injectable, biocompatible, and readily degradable into natural components that are easily metabolized by the body.
  • Huang Laboratory: Dr. Ngan Huang’s laboratory uses extracellular matrix proteins and biomaterials to study the effects of biophysical and biomechanical cues on mechanobiology and stem cell differentiation. Using the insights gained from these studies, Dr. Huang and her group hope to develop new therapies in tissue engineering and regenerative medicine.
  • Suggs Laboratory: Dr. Laura Suggs’ lab aims to develop clinically relevant and robust strategies for enhancing the growth of cardiac and vascular tissue in vivo to restore function after injuries such as myocardial infarction, ischemia, and deep burns. Toward this goal this lab studies the in vitro response of stem cells to pro-angiogenic gel materials that they have developed, explores new strategies to encourage stem cell differentiation to cardiomyocytes, and assesses the vessel forming ability of stem cells implanted within gel scaffolds in mouse injury models. They are also interested in creating novel self-assembling gel matrix materials for promoting angiogenesis that are injectable, biocompatible, and readily degradable into natural components that are easily metabolized by the body.
  • Zoldan Laboratory: Dr. Janet Zoldan, a bioengineer, focuses on human induced pluripotent stem cells (iPSCs) as a model system to explore key principles underlying tissue formation processes by integrating and applying materials and stem cell bioengineering. Understanding this process and controlling it is critical for treating a broad spectrum of pathological conditions. Current research includes using protein delivery to direct iPSCs differentiation into the cardiovascular lineages, mimicking the cardiac niche, and developing iPSC-derived tissue constructs for cardiac tissue repair and replacement.
  • Suggs Laboratory: Dr. Laura Suggs’ lab aims to develop clinically relevant and robust strategies for enhancing the growth of cardiac and vascular tissue in vivo to restore function after injuries such as myocardial infarction, ischemia, and deep burns. Toward this goal this lab studies the in vitro response of stem cells to pro-angiogenic gel materials that they have developed, explores new strategies to encourage stem cell differentiation to cardiomyocytes, and assesses the vessel forming ability of stem cells implanted within gel scaffolds in mouse injury models. They are also interested in creating novel self-assembling gel matrix materials for promoting angiogenesis that are injectable, biocompatible, and readily degradable into natural components that are easily metabolized by the body.
  • Terzic Laboratory: As a physician, Dr. Carmen Terzic specializes in cardiovascular rehabilitation and neuromuscular rehabilitation. As a scientist, her research is focused on developing regenerative medicine and stem cell-based cardiac repair and optimizes their properties for cardiac commitment, as well as studying the role of nuclear transport during stem cell differentiation into cardiomyocytes.
  • Zoldan Laboratory: Dr. Janet Zoldan, a bioengineer, focuses on human induced pluripotent stem cells (iPSCs) as a model system to explore key principles underlying tissue formation processes by integrating and applying materials and stem cell bioengineering. Understanding this process and controlling it is critical for treating a broad spectrum of pathological conditions. Current research includes using protein delivery to direct iPSCs differentiation into the cardiovascular lineages, mimicking the cardiac niche, and developing iPSC-derived tissue constructs for cardiac tissue repair and replacement.
  • Heilshorn Laboratory: Ongoing investigations from Dr. Sarah Heilshorn’s laboratory include Implantable materials for regenerative medicine, Injectable materials for cell transplantation, and Biotemplates for inorganic nanoparticles. Specifically, Dr. Heilshorn and her group are designing a new family of biomaterials that are made entirely of engineered proteins. Current systems under study include neuronal, cardiac, vascular, and bone tissues amongst others. In addition, the Heilshorn laboratory has research interests in the development of functional cell delivery materials to protect cells from mechanical stress during injection, localize them to the transplantation site, and direct their organization and differentiation in vivo thinning and self-healing.
  • Heilshorn Laboratory: Ongoing investigations from Dr. Sarah Heilshorn’s laboratory include Implantable materials for regenerative medicine, Injectable materials for cell transplantation, and Biotemplates for inorganic nanoparticles. Specifically, Dr. Heilshorn and her group are designing a new family of biomaterials that are made entirely of engineered proteins. Current systems under study include neuronal, cardiac, vascular, and bone tissues amongst others. In addition, the Heilshorn laboratory has research interests in the development of functional cell delivery materials to protect cells from mechanical stress during injection, localize them to the transplantation site, and direct their organization and differentiation in vivo thinning and self-healing.
  • Huang Laboratory: Dr. Ngan Huang’s laboratory uses extracellular matrix proteins and biomaterials to study the effects of biophysical and biomechanical cues on mechanobiology and stem cell differentiation. Using the insights gained from these studies, Dr. Huang and her group hope to develop new therapies in tissue engineering and regenerative medicine.
  • Terzic Laboratory: As a physician, Dr. Carmen Terzic specializes in cardiovascular rehabilitation and neuromuscular rehabilitation. As a scientist, her research is focused on developing regenerative medicine and stem cell-based cardiac repair and optimizes their properties for cardiac commitment, as well as studying the role of nuclear transport during stem cell differentiation into cardiomyocytes.
  • Huang Laboratory: Dr. Ngan Huang’s laboratory uses extracellular matrix proteins and biomaterials to study the effects of biophysical and biomechanical cues on mechanobiology and stem cell differentiation. Using the insights gained from these studies, Dr. Huang and her group hope to develop new therapies in tissue engineering and regenerative medicine.
  • Watkins Laboratory: Dr. Simon Watkins is the founder and director of the Center for Biologic Imaging at the University of Pittsburgh and a member of the Pittsburgh Cancer Institute.
  • Terzic Laboratory: As a physician, Dr. Carmen Terzic specializes in cardiovascular rehabilitation and neuromuscular rehabilitation. As a scientist, her research is focused on developing regenerative medicine and stem cell-based cardiac repair and optimizes their properties for cardiac commitment, as well as studying the role of nuclear transport during stem cell differentiation into cardiomyocytes.