AR3T’s research infrastructure provides investigators (you!) with access to state-of-the-art expertise from over twenty laboratories across the country working in the domain of Regenerative Rehabilitation.
AR3T’s Cores are designed to support the development of interdisciplinary research efforts, and we encourage you to contact us about collaborative projects, consultations, and sabbatical experiences that will strengthen current lines of research and support the development of new lines of Regenerative Rehabilitation research, to move the field forward. Select individual links below to learn more about researchers available to support your research endeavors.
Core 1: Cellular Therapeutics/Tissue Engineering
Directors: Dr. Thomas Rando (Stanford) and Dr. Carmen Terzic (Mayo). Expertise and training available in stem cell isolation, expansion, differentiation and characterization; the generation of induced pluripotent stem cells; protocols for genetic modification of precursor cells; protocols for the design and testing of tissue engineering protocols including scaffold design and implantation; and regulatory assistance and advice concerning clinical translation. Learn more:
Core 2: Mechanotransductive Methods
Directors: Dr. Fabrisia Ambrosio (University of Pittsburgh) and Dr. Linda Noble-Haeusslein (University of Texas). Expertise and training available in in vitro and in vivo methods to manipulate and measure cellular and tissue responses to mechanical loading and biophysical stimuli, as well as protocols for administering functional outcomes testing including in situ contractile testing, kinematic analysis, biomechanical testing of tendon and bone, and a suite of tests for assessing behavior in rodent models. Learn more:
Core 3: Rehabilitation & Mechanosensitive Biomarkers
Directors: Dr. Gwendolyn Sowa (University of Pittsburgh) and Dr. Michael Boninger (University of Pittsburgh). This Core, comprised of rehabilitation clinicians, biochemists, molecular biologists and bioengineers provides expertise to facilitate development of new model systems and supplies the unique resource of biomarker identification to facilitate titration of treatments for optimal biologic outcomes. These resources, coupled with rich experience in examining peripheral- (blood and urine) based biomarkers in response to treatments and as predictors to outcomes, provide the ability to fully translate our basic science knowledge of the benefits of Regenerative Rehabilitation to the clinic. Learn more: