Core Research Areas

Core Research Areas2018-06-18T14:45:31+00:00

The Regenerative Rehabilitation Cores are designed to enable exploration and development of interdisciplinary research efforts. AR3T encourages collaborative projects between our research Cores and investigators within the global research community in order to further the field of Regenerative Rehabilitation.

Please read about the different Core areas we have available as resources for you.

Core 1: Cellular Therapeutics/Tissue Engineering

Drs. Thomas Rando and Carmen Terzic are directors of the Cellular Therapies/Tissue Engineering Core. This Core offers expertise and training in stem cell isolation, expansion, differentiation and characterization; the generation of induced pluripotent stem cells; protocols for genetic modification of precursor cells; protocols for the design and testing of tissue engineering protocols including scaffold design and implantation; and regulatory assistance and advice concerning clinical translation.

Core 2: Mechanotransductive Methods

Drs. Fabrisia Ambrosio and Linda Noble-Haeusslein are directors of the Mechanotransductive Methods Core. This Core offers expertise in in vitro and in vivo methods to manipulate and measure cellular and tissue responses to mechanical loading and biophysical stimuli, as well as protocols for administering functional outcomes testing including in situ contractile testing, kinematic analysis, biomechanical testing of tendon and bone, and a suite of tests for assessing behavior in rodent models.

Core 3: Rehabilitation & Mechanosensitive Biomarkers

Drs. Gwendolyn Sowa and Michael Boninger are the directors of the Mechanosensitive Biomarkers Core. This Core, comprised of rehabilitation clinicians, biochemists, molecular biologists, and bioengineers provides expertise to facilitate development of new model systems and supplies the unique resource of biomarker identification to facilitate titration of treatments for optimal biologic outcomes. These resources, coupled with rich experience in examining peripheral (blood and urine) based biomarkers in response to treatments and as predictors to outcomes, provide the ability to fully translate our basic science knowledge of the benefits of regenerative rehabilitation to the clinic.