Publications and Resources

Publications and Resources2019-10-24T17:40:19+00:00

Click each heading to find a list of publications and resources.

  1. NEW! Potential Role of Physical Therapy in the Field of Genetic and Cellular Rehabilitation: A Review of Literature International Journal of Health Sciences and Research, 2019
  2. NEW! A Forward Move: Interfacing Biotechnology and Physical Therapy In and Out of the Classroom Physical Therapy, 2019
  3. NEW! Stem Cell Therapy for Knee Osteoarthritis: A Narrative Review of a Rapidly Evolving Treatment with Implications for Physical Therapy Management Physical Therapy Reviews, 2019
  4. NEW! Regenerative Medicine Curriculum for Next-generation Physicians npj Regenerative Medicine, 2019
  5.  Recreating Embryonic Conditions at Break Sites can Help Bones Heal Faster Science Daily, 2019
  6.  Regenerative Rehabilitation of the Musculoskeletal System Ovid, 2019
  7.  The Convergence of Regenerative Medicine and Rehabilitation: Federal Perspectives npj Regenerative Medicine, 2018
  8.  The Regenerative Rehabilitation Collection: A Forum for an Emerging Field npj Regenerative Medicine, 2018
  9.  Rehabilitation Following Regenerative Medicine Treatment for Knee Osteoarthritis-Current Concept Review Journal of Clinical Orthopaedics and Trauma, 2018
  10. Regenerative Rehabilitation: The Role of Mechanotransduction in Orthopaedic Regenerative Medicine  Journal of Orthopaedic Research, 2018
  11.  Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics Cell Stem Cell, 2018
  12.  Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity Dependent Simulation Pediatric Physical Therapy, 2017
  13. Cellular Rehab: Physical Therapy and Exercise are Critical to the Success of Cell Therapies Approaching the Clinic. The Scientist, 2015
  14. Regenerative Rehabilitation: A New Future? American Journal of Physical Medicine & Rehabilitation, 2014
  15. Opportunities for Regenerative Rehabilitation and Advanced Technologies in Physical Therapy: Perspective From Academia. Physical Therapy, 2016
  16. The Role of PTs in Regenerative Medicine PT in Motion, 2016
  17. The Role of Physiatry in Regenerative Medicine: The Past, The Present, and Future Challenges PM&R, 2015
  18. Regenerative Rehabilitation and Genomics: Frontiers in Clinical Practice. Physical Therapy, 2016
  19. Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships Physical Therapy, 2016
  20. Developmental Biology and Regenerative Medicine: Addressing the Vexing Problem of Persistent Muscle Atrophy in the Chronically Torn Human Rotator Cuff Physical Therapy, 2016
  21. Regenerative Principles Enrich Cardiac Rehabilitation Practice American Journal of Physical Medicine & Rehabilitation, 2015
  22. Emergent Themes from Second Annual Symposium on Regenerative Rehabilitation, Pittsburgh, Pennsylvania  Journal of Rehabilitation Research and Development, 2014
  23. Toward a Convergence of Regenerative Medicine, Rehabilitation, and Neuroprosthetics Journal of Neurotrauma, 2011
  24. The Emerging Relationships between Regenerative Medicine and Physical Therapeutics  Journal of Rehabilitation Research and Development, 2013
  25. Regenerative Rehabilitation: A Call To Action Journal of Rehabilitation Research and Development, 2010
  26. Youtube video collection on Regenerative Rehabilitation
  1. NEW! The Role of Reactive Oxygen Soecies in In Vitro Cardiac Maturation Trends in Molecular Medicine, 2019
  2. NEW! Updates in Multi-Disciplinary Approaches for Stem-Cell Based Cartilage Orthopedic Research Society, 2019
  3. NEW! Analysis and Modeling of Rat Gait Biomechanical Deficits in Response to Volumetric Muscle Loss Injury Frontiers in Bioengineering and Biotechnology, 2019
  4. NEW! Dynamic Compressive Loading Improves Cartilage Repair in an In Vitro Model of Microfracture: Comparison of 2 Mechanical Loading Regimens on Simulated Microfracture Based on Fibrin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells The American Journal of Sports Medicine, 2019
  5. NEW! Review of the Current Knowledge on the Role of Stem Cell Transplantation in Neurorehabilitation BioMed Research International, 2019
  6. NEW! Multi‐Disciplinary Approaches for Cell‐Based Cartilage Regeneration Journal of Orthopaedic Research, 2019
  7. NEW! Continuous Low-Intensity Ultrasound Promotes Native-To-Native Cartilage Integration Tissue Engineering Part A, 2019
  8. NEW! 6.5 Scientific Background of Physical and Rehabilitation Medicine: Rehabilitation Sciences The Journal of The International Society of Physical and Rehabilitation Medicine, 2019
  9. The Future of Animal Modeling for Post-Stroke Tissue Repair Stroke, 2018
  10.  PGC-1α Overexpression Partially Rescues Impaired Oxidative and Contractile Pathophysiology Following Volumetric Muscle Loss Injury Scientific Reports, 2018
  11. Production of Elastin-Like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D Journal of Visualized Experiments, 2018
  12. Rehabilitative Exercise and Spatially Patterned Nanofibrillar Scaffolds Enhance Vascularization and Innervation Following Volumetric Muscle Loss npj Regenerative Medicine, 2018
  13. Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA Tissue Engineering Part A, 2019
  14. Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration Advanced Healthcare Materials, 2019
  15. Extracellular Matrix Remodelling Induced by Alternating Electrical and Mechanical Stimulations Increases the Contraction of Engineered Skeletal Muscle Tissues Scientific Reports, 2019
  16. Translation of Remote Control Regenerative Technologies for Bone Repair npj Regenerative Medicine, 2018
  17. Rehabilitative Exercise and Spatially Patterned Nanofibrillar Scaffolds Enhance Vascularization and Innervation Following Volumetric Muscle Loss npj Regenerative Medicine, 2018
  18. Effectiveness of Mesenchymal Stem Cells for Treating Patients with Knee Osteoarthritis: A Meta-Analysis Toward the Establishment of Effective Regenerative Rehabilitation npj Regenerative Medicine, 2018
  19. Environmental Influences on Stem Cell Behavior Stem Cells International, 2018
  20. Early Rehabilitation for Volumetric Muscle Loss Injury Augments Regenerative Aspects of Muscle Strength and Oxidative Capacity  BMC Musculoskeletal Disorders, 2018
  21. Bioengineered Constructs Combined with Exercise Enhance Stem Cell-Mediated Treatment of Volumetric Muscle Loss Nature Communications, 2017
  22. Biological Effects of Dosing Aerobic Exercise and Neuromuscular Electrical Stimulation in Rats Scientific Reports, 2017
  23. Targeted Rehabilitation After Extracellular Matrix Scaffold Transplantation for the Treatment of Volumetric Muscle Loss American Journal of Physical Medicine and Rehabilitation, 2014
  24. Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted into Dystrophic Skeletal Muscle  PLOS ONE, 2013
  25. The Synergistic Effect of Treadmill Running on Stem-Cell Transplantation to Heal Injured Skeletal Muscle  Tissue Engineering Part A, 2010
  26. Interactive Effects of Cell Therapy and Rehabilitation Realize the Full Potential of Neurogenesis in Brain Injury Model  Neuroscience Letters, 2013
  27. Gene Therapy for Inherited Muscle Diseases: Where Genetics Meets Rehabilitation Medicine  American Journal of Physical Medicine and Rehabilitation, 2015
  28. Regenerative and Rehabilitative Medicine: A Necessary Synergy for Functional Recovery from Volumetric Muscle Loss Injury Cells Tissues Organs, 2015

AR3T has a Cellular Therapeutics/Tissue Engineering Core that has expertise and training in this area, with researchers who are available for consultations.

  1. NEW! Treatment of Volumetric Muscles Loss in Mice Using Nanofibrillar Scaffolds Enhances Vascular Organization and Integration Communications Biology, 2019
  2. NEW! Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies Journal of Orthopaedic Research, 2019
  3. NEW! A Roadmap for Promoting Endogenous in situ Tissue Restoration Using Inductive Bioscaffolds After Acute Brain Injury Brain Research Bulletin, 2019
  4. NEW! Review of the Current Knowledge on the Role of Stem Cell Transplantation in Neurorehabilitation BioMed Research International, 2019
  5. NEW! Multi‐Disciplinary Approaches for Cell‐Based Cartilage Regeneration Journal of Orthopaedic Research, 2019
  6. NEW! Stem cell therapy for knee osteoarthritis: a narrative review of a rapidly evolving treatment with implications for physical therapy management Physical Therapy Reviews, 2019
  7. NEW! Damaged muscle fibers might masquerade as hybrid fibers – a cautionary note on immunophenotyping mouse muscle with mouse monoclonal antibodies European Journal of Histochemistry, 2018
  8. NEW! In Vitro Repair of Meniscal Radial Tear With Hydrogels Seeded With Adipose Stem Cells and TGF-β3 The American Journal of Sports Medicine, 2018
  9. NEW! Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration Advanced Healthcare Materials, 2019
  10. NEW! Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA Tissue Engineering Part A, 2019
  11. NEW! Therapeutic Effects of Combined Cell Transplantation and Locomotor Training in Rats With Brain Injury npj Regenerative Medicine, 2019
  12. Regenerative Rehabilitation of the Musculoskeletal System American Academy of Orthopedic Surgery, 2018
  13. Production of Elastin-like Protein Hydrogels for Encapsulations and Immunostaining of Cells in 3D Journal of Visual Experiments, 2018
  14. An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss Science Translational Medicine, 2014
  15. Mesenchymal Stem Cells: Identification, Phenotypic Characterization, Biological Properties and Potential for Regenerative Medicine through Biomaterial Micro-Engineering of Their Niche Methods, 2016
  16. Stem Cells and Healthy Aging Science, 2015
  17. Extracellular Matrix Bioscaffolds in Tissue Remodeling and Morphogenesis Developmental Dynamics, 2015
  18. Biologic Scaffolds for Regenerative Medicine: Mechanisms of In vivo Remodeling Annals of Biomedical Engineering, 2014
  19. Cell-Derived Matrices for Tissue Engineering and Regenerative Medicine Applications Biomaterials Science, 2015
  20. Sexual Dimorphism in Stem Cell-Based Therapies for the Musculoskeletal System Operative Techniques in Orthopaedics, 2016
  21. Cell-Derived Extracellular Matrix: Basic Characteristics and Current Applications in Orthopedic Tissue Engineering Tissue Engineering Part B: Reviews, 2016
  22. Biomaterials Control of Pluripotent Stem Cell Fate for Regenerative Therapy Progress in Materials Science, 2016
  23. Intracerebral Cell Implantation: Preparation and Characterization of Cell Suspensions Cell Transplantation, 2016
  24. Stem Cells in Skeletal Tissue Engineering: Technologies and Models  Current Stem Cell Research and Therapy, 2016
  25. Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease Annual Review of Biomedical Engineering, 2015
  26. Youtube Video Collection on Tissue Engineering and Cellular Therapeutics

AR3T has a Mechanotransductive Core that has expertise in this area, with researchers who are available to provide consultations.

  1. NEW! Effects of Treadmill Running and Limb Immobilization on Knee Cartilage Degeneration and Locomotor Joint Kinematics in Rats Following Knee Meniscal Transection Osteoarthritis and Cartilage, 2019
  2. NEW! Real-Time Monitoring of Mechanical Cues in the Regenerative Niche Reveal Dynamic Strain Magnitudes that Enhance Bone Repair bioRxiv, 2019
  3. Soft Tissue Manipulation: A Powerful Form of Mechanotherapy Journal of Physiotherapy and Physical Rehabilitation, 2016
  4. Biomechanical Stimulus Based Strategies for Meniscus Tissue Engineering and Regeneration Tissue Engineering Part B: Reviews, 2018
  5. Enhanced Neural Stem Cell Functions in Conductive Annealed Carbon Nanofibrous Scaffolds with Electrical Stimulation Nanomedicine: Nanotechnology, Biology and Medicine, 2018
  6. A Guide for Using Mechanical Stimulation to Enhance Tissue-Engineered Articular Cartilage Properties Tissue Engineering Part B: Reviews, 2018
  7. Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation  Physical Therapy, 2016
  8. Mechanotransduction: Relevance to Physical Therapist Practice—Understanding Our Ability to Affect Genetic Expression Through Mechanical Forces Physical Therapy, 2016
  9. Force Transmission in Epithelial Tissues Developmental Dynamics, 2016
  10. Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli PLOS ONE, 2017
  11. Mechanical and Vascular Cues Synergistically Enhance Osteogenesis in Human Mesenchymal Stem Cells  Tissue Engineering Part A, 2016
  12. Asymmetrical Seeding of MSCs into Fibrin–Poly(Ester-Urethane) Scaffolds and Its Effect on Mechanically Induced Chondrogenesis Journal of Tissue Engineering and Regenerative Medicine, 2016
  13. Gene Therapy for Inherited Muscle Diseases: Where Genetics Meets Rehabilitation Medicine American Journal of Physical Medicine and Rehabilitation, 2014
  14. Youtube video collection on Mechanobiology and Mechanotransduction
  15. Cell Mechanosensitivity to Extremely Low-Magnitude Signals is Enabled by a LINCed Nucleus Stem Cells, 2015
  16. Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage Stem Cells, 2016
  17. The Nucleus is a Conserved Mechanosensation and Mechanoresponse Organelle Cytoskeleton, 2016
  18. Bone and Skeletal Muscle: Key Players in Mechanotransduction and Potential Overlapping Mechanisms Bone, 2015

AR3T has a Biomarker Core that has expertise in this area, with researchers who are available to provide consultations.

  1. NEW! Identification of miRNA Reference Genes in Extracellular Vesicles from Adipose Derived Mesenchymal Stem Cells for Studying Osteoarthritis International Journal of Molecular Sciences, 2019
  2. ‘Longevity Protein’ Enables Muscle Regeneration In Old Mice Forbes, 2018
  3. The Development of Biomarkers for Degenerative Musculoskeletal Conditions Discovery Medicine, 2014
  4. NF-κB Signaling Pathway in Controlling Intervertebral Disk Cell Response to Inflammatory and Mechanical Stressors Physical Therapy, 2016
  5. Biomarker Development for Musculoskeletal Diseases PM&R, 2011
  6. Associations Between Serum Biomarkers and Pain and Pain-Related Function in Older Adults with Low Back Pain: A Pilot Study Journal of the American Geriatrics Society, 2014
  7. Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease Cell Metabolism, 2016
  8. Non-CG DNA Methylation is a Biomarker for Assessing Endodermal Differentiation Capacity in Pluripotent Stem Cells Nature Communications, 2016

Rehabilomics Research:

  1. A Rehabilomics Framework for Personalized and Translational Rehabilitation Research and Care for Individuals With Disabilities: Perspectives and Considerations for Spinal Cord Injury The Journal of Spinal Cord Medicine, 2014
  2. Rehabilomics Research: A Model for Translational Rehabilitation and Comparative Effectiveness Rehabilitation Research abstract American Journal of Physical Medicine and Rehabilitation, 2014

AR3T supports technology development for this purpose.

  1. NEW! Development and characterization of ZnO piezoelectric thin films on polymeric substrates for tissue repair Journal of Biomedical Materials Research, 2019
  2. NEW! An In Vitro 3D Model and Computational Pipeline to Quantify the Vasculogenic Potential of iPSC-Derived Endothelial Progenitors JoVE, 2019
  3. NEW! A Short-Term Plastic Adherence Incubation of the Stromal Vascular Fraction Leads to a Predictable GMP-Compliant Cell-Product Bioimpacts, 2019
  4. NEW! Raman Spectroscopy As a Quick Tool to Assess Purity of Extracellular Vesicle Preparations and Predict Their Functionality Journal of Exracellular Vesicles, 2019
  5. NEW! Measuring Clinically Relevant Knee Motion with a Self-Calibrated Wearable Sensor Journal of Biomechanics, 2019
  6. NEW! Analysis and Modeling of Rat Gait Biomechanical Deficits in Response to Volumetric Muscle Loss Injury Frontiers in Bioengineering and Biotechnology, 2019
  7. NEW! Dynamic Compressive Loading Improves Cartilage Repair in an In Vitro Model of Microfracture: Comparison of 2 Mechanical Loading Regimens on Simulated Microfracture Based on Fibrin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells The American Journal of Sports Medicine, 2019
  8. NEW! Continuous Low-Intensity Ultrasound Promotes Native-To-Native Cartilage Integration Tissue Engineering Part A, 2019
  9. Real-Time Monitoring of Mechanical Cues in the Regenerative Niche Reveal Dynamic Strain Magnitudes that Enhance Bone Repair bioRxiv, 2019
  10. Minimally Invasive Muscle Embedding (MIME) – A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis Journal of Visualized Experiments, 2018
  11. Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D Journal of Visualized Experiments, 2018
  12. Translation of Remote Control Regenerative Technologies for Bone Repair npj Regenerative Medicine, 2018
  13. Wearable Bioreactor Heralds Leap for Regenerative Medicine The Engineer, 2018
  14. EGaIn‐Assisted Room‐Temperature Sintering of Silver Nanoparticles for Stretchable, Inkjet‐Printed, Thin‐Film Electronics Advanced Materials, 2018
  15. Microfluidic Flow Cell Array for Controlled Cell Deposition in Engineered Musculoskeletal Tissues Tissue Engineering Part C: Methods, 2018
  16. Production of Elastin-like Protein Hydrogels for Encapsulations and Immunostaining of Cells in 3D Journal of Visualized Experiments, 2018
  17. Murine Model of Robotic Training to Evaluate Skeletal Muscle Recovery After Injury Medicine and Science in Sports and Exercise, 2017
  18. Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli PLOS ONE, 2017
  19. A Bird’s Eye View on the Use of Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering: Current State-of-the-Are, Emerging Directions and Future Trends Nanomedicine: Nanotechnology, Biology and Medicine, 2016
  20. High Throughput Screening for Discovery of Materials That Control Stem Cell Fate Current Opinion in Solid State and Materials Science, 2016
  21. A Review of Three-Dimensional Printing in Tissue Engineering Tissue Engineering Part B: Reviews, 2016
  22. Advanced Imaging Approaches for Regenerative Medicine: Emerging Technologies for Monitoring Stem Cell Fate In Vitro and In Vivo Biotechnology Journal, 2015
  23. Electrodiagnostic Evaluation of Individuals Implanted With Extracellular Matrix for the Treatment of Volumetric Muscle Injury: Case Series Physical Therapy, 2016
  24. Youtube video collection on Regenerative Medicine research technology
    1. NEW! Should Platelet-Rich Plasma or Stem Cell Therapy Be Used to Treat Osteoarthritis? Rheumatic Disease Clinics, 2019
    2. NEW! Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies Journal of Orthopaedic Research, 2019
    3. NEW! A Roadmap for Promoting Endogenous in situ Tissue Restoration Using Inductive Bioscaffolds After Acute Brain Injury Brain Research Bulletin, 2019
    4. NEW! New Biotechnologies for Musculoskeletal Injuries The Surgeon, 2019
    5. NEW! Regenerative medicine curriculum for next-generation physicians npj Regenerative Medicine, 2019
    6. NEW! Minimally Invasive Muscle Embedding (MIME), Facilitates the Development of Functional Muscle Fibers of Human Cadaveric Origin, in Host Mice The FASEB Journal, 2019
    7. NEW! The Oriobiologic Institute 9th Annual PRP & Regenerative Medicine Symposium (TOBI 2018): Compendium of Abstracts Biologic Orthopedic Journal, 2019
    8. Minimally Invasive Muscle Embedding (MIME) – A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis  Journal of Visualized Experiments, 2017
    9. Cytokine Networks in Immune-Mediated Muscle Regeneration Journal of Immunology and Regenerative Medicine, 2018
    10.  Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis Stem Cells Translational Medicine, 2017
    11. Mesenchymal Stem Cells: Identification, Phenotypic Characterization, Biological Properties and Potential for Regenerative Medicine through Biomaterial Micro-Engineering of Their Niche Methods, 2016
    12. Youtube Video Collection on the Topic of Regenerative Medicine
    13. Regenerative Medicine and Regenerative Rehabilitation Podcast collection
      1. Dr. Fabrisia Ambrosio -Regenerative Rehabilitation #97
      2. Dr. Tom Rando -muscle stem cell biology #111
      3. Dr. Steve Wolf  -Regenerative Rehabilitation and educating clinicians #112
      4. Dr. George Christ -musculoskeletal tissue engineering #115
      5. Dr. Michel Modo -stem cell therapy, neuroimaging and stroke #117
      6. Dr. Ravi Bellamkonda -nerve gap repair #121
      7. Dr. Jonathan Cheetham -TE for larynx, nasopharynx and trachea #124
      8. Dr. Linda Noble- Haeusslein -CNS injuries #129
      9. Dr. David Borton -spinal injuries and Regenerative Rehabilitation #133
      10. Patrick Cantini -muscle tissue engineering study #141
      11. Dr. Stephen Badylak –npj Regenerative Medicine #154
      12. Dr. Michael Boninger -Regenerative Rehabilitation #155
      13. Dr. Elisabeth Barton -skeletal muscle repair #158
      14. Dr. Rocky Tuan -musculoskeletal disorders #166
      15. Drs. Lorenzo Soletti and Bryan Brown -peripheral nerve repair #175
      16. Dr. Antonio D’Amore -artificial heart valves and cardiac patches #178
      17. Dr. Fatima Syed-Picard -craniofacial tissue engineering #179
      18. Dr. Stephen Badylak –Journal of Immunology and Regenerative Medicine #182
  1. American Regenerative Rehabilitation and GenomicsAcademy of Physical Medicine and Rehabilitation (AAPM&R)
  2. American Physical Therapy Association (APTA)
  3. International Society for Stem Cell Research
  4. McGowan Institute for Regenerative Medicine
  5. Medical Rehabilitation Research Resource Network (MR3)
  6. RegenerativeMedicine.net
  7. RegMedNet: At RegMedNet we truly believe that regenerative medicine is going to revolutionize modern healthcare. The field comprises a multidisciplinary mix of experts, from regulators to manufacturers to researchers: RegMedNet is a networking site that unites all members of the diverse regenerative medicine community, enabling them to share the latest news, inspiration and insights, and connect and collaborate in order to help this exciting field move forward at an even faster rate.